HLA polymorphism in six ethnic groups from Pakistan
Identifieur interne : 000E53 ( Main/Exploration ); précédent : 000E52; suivant : 000E54HLA polymorphism in six ethnic groups from Pakistan
Auteurs : A. Mohyuddin [Pakistan] ; Q. Ayub [Pakistan] ; S. Khaliq [Pakistan] ; A. Mansoor [Pakistan] ; K. Mazhar [Pakistan] ; S. Rehman [Pakistan] ; S. Q. Mehdi [Pakistan]Source :
- Tissue Antigens [ 0001-2815 ] ; 2002-06.
Descripteurs français
- Wicri :
- geographic : Pakistan.
English descriptors
Abstract
Abstract: The extreme polymorphism found at some of the loci of the HLA system has made it an invaluable tool for population genetic analyses. In this study the genetic polymorphism of six Pakistani ethnic groups was investigated at the HLA‐A, ‐B, ‐C, ‐DRB and DQB1 loci using polymerase chain reaction with sequence specific primers. The groups included in this study are the Baloch, Brahui and Sindhi from the south and the Burusho, Kalash and Pathan from the north of Pakistan. The allele frequencies, three‐locus haplotype frequencies for HLA‐A, ‐C, ‐B and HLA‐A, ‐B, ‐DRB1 are given. Variation in the allele and haplotype distribution between the six Pakistani ethnic groups was observed. A phylogenetic tree and correspondence analysis based on HLA‐A, ‐B, ‐C, ‐DRB1 and ‐DQB1 allele frequencies revealed the Kalash population to be distinct from the remaining Pakistani populations. The Baloch and Brahui were closely related to one another. The Sindhi were closer to the Pathan and Burusho populations than to the neighboring Baloch and Brahui populations, indicating admixture between the northern and southern populations of Pakistan. A phylogenetic tree and correspondence analysis comparing the Pakistani populations with various other world populations showed that the Pakistani ethnic groups lie within the cluster of Asian Indian populations. The three‐locus haplotypes found in the Pakistani populations suggest an influence from Caucasian and Oriental populations.
Url:
DOI: 10.1034/j.1399-0039.2002.590606.x
Affiliations:
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Khan Research Laboratories, PO Box 2891, Islamabad‐44000</wicri:regionArea><wicri:noRegion>Islamabad‐44000</wicri:noRegion></affiliation></author><author><name sortKey="Rehman, S" sort="Rehman, S" uniqKey="Rehman S" first="S." last="Rehman">S. Rehman</name><affiliation wicri:level="1"><country xml:lang="fr">Pakistan</country><wicri:regionArea>Biomedical and Genetic Engineering Division,Dr A. Q. Khan Research Laboratories, PO Box 2891, Islamabad‐44000</wicri:regionArea><wicri:noRegion>Islamabad‐44000</wicri:noRegion></affiliation></author><author><name sortKey="Mehdi, S Q" sort="Mehdi, S Q" uniqKey="Mehdi S" first="S. Q." last="Mehdi">S. Q. Mehdi</name><affiliation wicri:level="1"><country xml:lang="fr">Pakistan</country><wicri:regionArea>Biomedical and Genetic Engineering Division,Dr A. Q. Khan Research Laboratories, PO Box 2891, Islamabad‐44000</wicri:regionArea><wicri:noRegion>Islamabad‐44000</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Tissue Antigens</title><idno type="ISSN">0001-2815</idno><idno type="eISSN">1399-0039</idno><imprint><publisher>Munksgaard International Publishers</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2002-06">2002-06</date><biblScope unit="volume">59</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="492">492</biblScope><biblScope unit="page" to="501">501</biblScope></imprint><idno type="ISSN">0001-2815</idno></series><idno type="istex">449C36EA1378F4B96806C39F0B5D457917E2B8E6</idno><idno type="DOI">10.1034/j.1399-0039.2002.590606.x</idno><idno type="ArticleID">tan2o012</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0001-2815</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>HLA haplotypes</term><term>HLA polymorphism</term><term>Pakistan</term><term>population genetics</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Pakistan</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Abstract: The extreme polymorphism found at some of the loci of the HLA system has made it an invaluable tool for population genetic analyses. In this study the genetic polymorphism of six Pakistani ethnic groups was investigated at the HLA‐A, ‐B, ‐C, ‐DRB and DQB1 loci using polymerase chain reaction with sequence specific primers. The groups included in this study are the Baloch, Brahui and Sindhi from the south and the Burusho, Kalash and Pathan from the north of Pakistan. The allele frequencies, three‐locus haplotype frequencies for HLA‐A, ‐C, ‐B and HLA‐A, ‐B, ‐DRB1 are given. Variation in the allele and haplotype distribution between the six Pakistani ethnic groups was observed. A phylogenetic tree and correspondence analysis based on HLA‐A, ‐B, ‐C, ‐DRB1 and ‐DQB1 allele frequencies revealed the Kalash population to be distinct from the remaining Pakistani populations. The Baloch and Brahui were closely related to one another. The Sindhi were closer to the Pathan and Burusho populations than to the neighboring Baloch and Brahui populations, indicating admixture between the northern and southern populations of Pakistan. A phylogenetic tree and correspondence analysis comparing the Pakistani populations with various other world populations showed that the Pakistani ethnic groups lie within the cluster of Asian Indian populations. The three‐locus haplotypes found in the Pakistani populations suggest an influence from Caucasian and Oriental populations.</div></front></TEI><affiliations><list><country><li>Pakistan</li></country></list><tree><country name="Pakistan"><noRegion><name sortKey="Mohyuddin, A" sort="Mohyuddin, A" uniqKey="Mohyuddin A" first="A." last="Mohyuddin">A. Mohyuddin</name></noRegion><name sortKey="Ayub, Q" sort="Ayub, Q" uniqKey="Ayub Q" first="Q." last="Ayub">Q. Ayub</name><name sortKey="Khaliq, S" sort="Khaliq, S" uniqKey="Khaliq S" first="S." last="Khaliq">S. Khaliq</name><name sortKey="Mansoor, A" sort="Mansoor, A" uniqKey="Mansoor A" first="A." last="Mansoor">A. Mansoor</name><name sortKey="Mazhar, K" sort="Mazhar, K" uniqKey="Mazhar K" first="K." last="Mazhar">K. Mazhar</name><name sortKey="Mehdi, S Q" sort="Mehdi, S Q" uniqKey="Mehdi S" first="S. Q." last="Mehdi">S. Q. Mehdi</name><name sortKey="Rehman, S" sort="Rehman, S" uniqKey="Rehman S" first="S." last="Rehman">S. Rehman</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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